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Article

Metrical Consistency NMF for Predicting Gene-Phenotype Associations.

Interdisciplinary sciences, computational life sciences - 1 Mar 2018

Han Shuai, Cai Hong, Che Dan, Zhang Yaogong, Huang Yalou, Xie Maoqiang

Abstract excerpt

Discovering gene-phenotype associations is significant to understand the disease mechanisms. Nonnegative matrix factorization (NMF) has been widely used in computational biology for its good performance and interpretability. In this paper, we proposed a novel metrical consistency NMF (MCNMF) method for candidate gene prioritization. The MCNMF method assume that phenotype similarities, calculated from various...

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PMID: 28391494
DOI: 10.1007/s12539-017-0224-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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