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Article

Transcriptomic buffering of cryptic genetic variation contributes to meningococcal virulence.

BMC genomics - 7 Apr 2017

Ampattu Biju Joseph, Hagmann Laura, Liang Chunguang, Dittrich Marcus, Schlüter Andreas, Blom Jochen, Krol Elizaveta, Goesmann Alexander, Becker Anke, Dandekar Thomas, Müller Tobias, Schoen Christoph

Abstract excerpt

BACKGROUND: Commensal bacteria like Neisseria meningitidis sometimes cause serious disease. However, genomic comparison of hyperinvasive and apathogenic lineages did not reveal unambiguous hints towards indispensable virulence factors. Here, in a systems biological approach we compared gene expression of the invasive strain MC58 and the carriage strain α522 under different ex vivo conditions mimicking commensal...

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Identifiers

PMID: 28388876
DOI: 10.1186/s12864-017-3616-7
PMCID: PMC5383966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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