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Article

The genetic landscape of anaplastic astrocytoma.

Oncotarget - 30 Mar 2014

Killela Patrick J, Pirozzi Christopher J, Reitman Zachary J, Jones Sian, Rasheed B Ahmed, Lipp Eric, Friedman Henry, Friedman Allan H, He Yiping, McLendon Roger E, Bigner Darell D, Yan Hai

Abstract excerpt

Anaplastic astrocytoma WHO grade III (A3) is a lethal brain tumor that often occurs in middle aged patients. Clinically, it is challenging to distinguish A3 from glioblastoma multiforme (GBM) WHO grade IV. To reveal the genetic landscape of this tumor type, we sequenced the exome of a cohort of A3s (n=16). For comparison and to illuminate the genomic landscape of other glioma subtypes, we also included in our...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24140581
DOI: 10.18632/oncotarget.1505
PMCID: PMC4039223

Genes

ATRX
IDH1
NOTCH1
NOTCH2
NOTCH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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