Clinico-genetic findings in 509 frontotemporal dementia patients.

doi:10.1038/s41380-021-01271-2

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Clinico-genetic findings in 509 frontotemporal dementia patients.

Molecular psychiatry - 1 Oct 2021

Wagner Matias, Lorenz Georg, Volk Alexander E, Brunet Theresa, Edbauer Dieter, Berutti Riccardo, Zhao Chen, Anderl-Straub Sarah, Bertram Lars, Danek Adrian, Deschauer Marcus, Dill Veronika, Fassbender Klaus, Fliessbach Klaus, Götze Katharina S, Jahn Holger, Kornhuber Johannes, Landwehrmeyer Bernhard, Lauer Martin, Obrig Hellmuth, Prudlo Johannes, Schneider Anja, Schroeter Matthias L, Uttner Ingo, Vukovich Ruth, Wiltfang Jens, Winkler Andrea S, Zhou Qihui, Ludolph Albert C, Oexle Konrad, Otto Markus, Diehl-Schmid Janine, Winkelmann Juliane

Abstract excerpt

Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To which extent genetic aberrations dictate clinical presentation remains elusive. We investigated the spectrum of genetic causes and assessed the genotype-driven differences in biomarker profiles, disease severity and clinical manifestation by recruiting 509 FTD patients from different centers of the German FTLD consortium...

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PMID: 34561610
DOI: 10.1038/s41380-021-01271-2
PMCID: PMC8758482

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