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Article

Mouse fitness measures reveal incomplete functional redundancy of Hox paralogous group 1 proteins.

PloS one - 1 Jan 2017

Ruff James S, Saffarini Raed B, Ramoz Leda L, Morrison Linda C, Baker Shambralyn, Laverty Sean M, Tvrdik Petr, Capecchi Mario R, Potts Wayne K

Abstract excerpt

Here we assess the fitness consequences of the replacement of the Hoxa1 coding region with its paralog Hoxb1 in mice (Mus musculus) residing in semi-natural enclosures. Previously, this Hoxa1B1 swap was reported as resulting in no discernible embryonic or physiological phenotype (i.e., functionally redundant), despite the 51% amino acid sequence differences between these two Hox proteins. Within heterozygous...

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Identifiers

PMID: 28380068
DOI: 10.1371/journal.pone.0174975
PMCID: PMC5381901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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