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Article

Fitness Assays Reveal Incomplete Functional Redundancy of the HoxA1 and HoxB1 Paralogs of Mice.

Genetics - 1 Oct 2015

Ruff James S, Saffarini Raed B, Ramoz Leda L, Morrison Linda C, Baker Shambralyn, Laverty Sean M, Tvrdik Petr, Potts Wayne K

Abstract excerpt

Gene targeting techniques have led to the phenotypic characterization of numerous genes; however, many genes show minimal to no phenotypic consequences when disrupted, despite many having highly conserved sequences. The standard explanation for these findings is functional redundancy. A competing hypothesis is that these genes have important ecological functions in natural environments that are not needed under...

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Identifiers

PMID: 26447130
DOI: 10.1534/genetics.115.178079
PMCID: PMC4596679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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