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Article

Double Mutant Cycles as a Tool to Address Folding, Binding, and Allostery.

International journal of molecular sciences - 15 Jan 2021

Pagano Livia, Toto Angelo, Malagrinò Francesca, Visconti Lorenzo, Jemth Per, Gianni Stefano

Abstract excerpt

Quantitative measurement of intramolecular and intermolecular interactions in protein structure is an elusive task, not easy to address experimentally. The phenomenon denoted 'energetic coupling' describes short- and long-range interactions between two residues in a protein system. A powerful method to identify and quantitatively characterize long-range interactions and allosteric networks in proteins or...

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Identifiers

PMID: 33467625
DOI: 10.3390/ijms22020828
PMCID: PMC7830974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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