Article
Febrile temperatures unmask biophysical defects in Nav1.1 epilepsy mutations supportive of seizure initiation.
The Journal of general physiology - 1 Dec 2013
Volkers Linda, Kahlig Kristopher M, Das Joost H G, van Kempen Marjan J A, Lindhout Dick, Koeleman Bobby P C, Rook Martin B
Abstract excerpt
Generalized epilepsy with febrile seizures plus (GEFS+) is an early onset febrile epileptic syndrome with therapeutic responsive (a)febrile seizures continuing later in life. Dravet syndrome (DS) or severe myoclonic epilepsy of infancy has a complex phenotype including febrile generalized or hemiclonic convulsions before the age of 1, followed by intractable myoclonic, complex partial, or absence seizures. Both...
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