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Article

Does a SCN1A gene mutation confer earlier age of onset of febrile seizures in GEFS+?

Epilepsia - 1 Apr 2009

Sijben Angelique E J, Sithinamsuwan Pasiri, Radhakrishnan Ashalata, Badawy Radwa A B, Dibbens Leanne, Mazarib Aziz, Lev Dorit, Lerman-Sagie Tally, Straussberg Rachel, Berkovic Samuel F, Scheffer Ingrid E

Abstract excerpt

SCN1A is the most clinically relevant epilepsy gene and is associated with generalized epilepsy and febrile seizure plus (GEFS+) and Dravet syndrome. We postulated that earlier onset of febrile seizures in the febrile seizure (FS) and febrile seizure plus (FS+) phenotypes may occur in the presence of a SCN1A mutation. This was because of the age-related onset of Dravet syndrome, which typically begins in the...

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Share to Confidence Intervals
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epilepsy, Generalized

Share to NAV1.1 Voltage-Gated Sodium Channel

Share to Receptors, GABA-A

Share to Seizures, Febrile

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Source

Identifiers

PMID: 19292758
DOI: 10.1111/j.1528-1167.2009.02023.x

Genes

GABRG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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