Recommendations on the Implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes.

doi:10.1002/cbic.201700013

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Article

Recommendations on the Implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes.

Chembiochem : a European journal of chemical biology - 19 Jun 2017

Barley Mark H, Turner Nicolas J, Goodacre Royston

Abstract excerpt

In directed evolution (DE) the assessment of candidate enzymes and their modification is essential. In this study we have investigated genetic algorithms (GAs) in this context and conducted a systematic study of the behavior of GAs on 20 fitness landscapes (FLs) of varying complexity. This has allowed the tuning of the GAs to be explored. On the basis of this study, recommendations for the best GA settings to use...

Topics

Algorithms
Directed Molecular Evolution
Epoxide Hydrolases
Gene Expression
High-Throughput Screening Assays
Linear Models
Models, Genetic
Mutation
Principal Component Analysis

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Open in PubMed

Identifiers

PMID: 28371130
DOI: 10.1002/cbic.201700013

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