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Increasing mitochondrial superoxide dismutase abundance leads to impairments in protein quality control and ROS scavenging systems and to lifespan shortening.

Experimental gerontology - 1 Aug 2010

Zintel Sandra, Schwitalla Denise, Luce Karin, Hamann Andrea, Osiewacz Heinz D

Abstract excerpt

The fungal aging model Podospora anserina contains three superoxide dismutases (SODs) in different cellular compartments. While PaSOD1 represents the Cu/Zn isoform located in the cytoplasm and in the mitochondrial inter-membrane space, PaSOD2 localizes to the perinuclear ER. PaSOD3, a protein with a manganese binding domain and a mitochondrial targeting sequence (MTS) is the mitochondrial SOD. Over-expression of...

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PMID: 20080171
DOI: 10.1016/j.exger.2010.01.006

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