Polymorphism in the Alternative Donor Site of the Cryptic Exon of LHCGR: Functional Consequences and Associations with Testosterone Level.

doi:10.1038/srep45699

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Polymorphism in the Alternative Donor Site of the Cryptic Exon of LHCGR: Functional Consequences and Associations with Testosterone Level.

Scientific reports - 3 Apr 2017

Liu Wei, Han Bing, Zhu Wenjiao, Cheng Tong, Fan Mengxia, Wu Jiajun, Yang Ying, Zhu Hui, Si Jiqiang, Lyu Qifeng, Chai Weiran, Zhao Shuangxia, Song Huaidong, Kuang Yanping, Qiao Jie

Abstract excerpt

Selective splicing is a feature of luteinizing hormone receptor (LHCGR). A cryptic exon (LHCGR-exon 6A) was found to be derived from alternative splicing in intron 6 of the LHCGR gene, which including two transcripts LHCGR-exon 6A-long and LHCGR-exon 6A-short. We addressed the functional consequences of SNP rs68073206, located at the +5 position of an alternative 5' splice donor site, and observed its association...

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PMID: 28367994
DOI: 10.1038/srep45699
PMCID: PMC5377329

Genes

LHCGR

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