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Article

Functional implications of Neandertal introgression in modern humans.

Genome biology - 3 Apr 2017

Dannemann Michael, Prüfer Kay, Kelso Janet

Abstract excerpt

BACKGROUND: Admixture between early modern humans and Neandertals approximately 50,000-60,000 years ago has resulted in 1.5-4% Neandertal ancestry in the genomes of present-day non-Africans. Evidence is accumulating that some of these archaic alleles are advantageous for modern humans, while others are deleterious; however, the major mechanism by which these archaic alleles act has not been fully explored....

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Identifiers

PMID: 28366169
DOI: 10.1186/s13059-017-1181-7
PMCID: PMC5376702

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