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Article

Association of LDLR and SCARB1 gene polymorphisms with hepatocellular carcinoma: a case-control study proposing a 'double-hit' model.

Lipids in health and disease - 11 Apr 2026

Altintas Zuhal, Cevik Muammer Ozgur, Derici Eker Ebru, Altintas Engin

Abstract excerpt

BACKGROUND: Low-density lipoprotein receptor (LDLR) and scavenger receptor class B member 1 (SCARB1) are essential regulators of systemic lipid homeostasis. Although dysregulated lipid metabolism is a hallmark of malignancy, the genetic associations between these receptors and the risks of hepatocellular carcinoma (HCC) remain poorly understood. This study aimed to evaluate the impacts of LDLR and SCARB1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41965662
DOI: 10.1186/s12944-026-02946-x
PMCID: PMC13188632

Genes

LDLR
SCARB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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