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Maternofetal transport of vitamin B 12 : role of TCblR/ CD320 and megalin

28 Mar 2017

Abstract excerpt

ABSTRACT Vitamin B 12 deficiency causes megaloblastic anemia and neurologic disorder in humans. Gene defects of transcobalamin (TC) and the transcobalamin receptor (TCblR), needed for cellular uptake of the TC‐bound B 12 , do not confer embryonic lethality. TC deficiency can produce the hematologic and neurologic complications after birth, whereas TCblR/ CD320 gene defects appear to produce mild metabolic...

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PMID: 28351841
DOI: 10.1096/fj.201700025r

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