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Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment

28 Mar 2017

Abstract excerpt

Global but predictable changes impact the DNA methylome as we age, acting as a type of molecular clock. This clock can be hastened by conditions that decrease lifespan, raising the question of whether it can also be slowed, for example, by conditions that increase lifespan. Mice are particularly appealing organisms for studies of mammalian aging; however, epigenetic clocks have thus far been formulated only in...

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PMID: 28351423
DOI: 10.1186/s13059-017-1186-2

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