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Article

The Role of Pharmacotherapeutic Agents in Children with Desmoid Tumors.

Paediatric drugs - 1 Sept 2022

Douglass David P, Navid Fariba, Weiss Aaron R

Abstract excerpt

Desmoid tumors (DT) are rare fibroblastic, soft-tissue tumors that do not metastasize but can aggressively infiltrate tissues causing significant chronic discomfort and/or functional impairment. In the pediatric population, the incidence of DT is greatest during infancy and adolescence but can occur at any age. Dysregulated β-catenin, most commonly resulting from mutations in either CTNNB1 or germline APC...

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PMID: 35902507
DOI: 10.1007/s40272-022-00526-x

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