Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant CTP:Phosphocholine Cytidylyltransferase.

PloS one - 1 Jan 2015

Marton Lívia, Nagy Gergely N, Ozohanics Olivér, Lábas Anikó, Krámos Balázs, Oláh Julianna, Vékey Károly, Vértessy Beáta G

Abstract excerpt

Control and elimination of malaria still represents a major public health challenge. Emerging parasite resistance to current therapies urges development of antimalarials with novel mechanism of action. Phospholipid biosynthesis of the Plasmodium parasite has been validated as promising candidate antimalarial target. The most prevalent de novo pathway for synthesis of phosphatidylcholine is the Kennedy pathway....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to CHO Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetulus

Share to Enzyme Stability

Share to Molecular Dynamics Simulation

Share to Plasmodium falciparum

Share to Protein Multimerization

Share to Protein Structure, Quaternary

Source

Open in PubMed Open full text

Identifiers

PMID: 26083347
DOI: 10.1371/journal.pone.0129632
PMCID: PMC4470507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant CTP:Phosphocholine Cytidylyltransferase.PMID 26083347Read ↗

Heterologous expression of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum rescues Chinese Hamster Ovary cells deficient in the Kennedy phosphatidylcholine biosynthesis pathway.Semantic proximity Read ↗

Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii.Semantic proximity Read ↗

Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold.Semantic proximity Read ↗

Cloning and characterization of a lipid-activated CTP:phosphocholine cytidylyltransferase from Caenorhabditis elegans: identification of a 21-residue segment critical for lipid activation.Semantic proximity Read ↗

Cryo-EM structure of the ATP11C Q79E mutant reveals the structural basis for altered Phospholipid recognition.Semantic proximity Read ↗

In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway.Semantic proximity Read ↗

The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparumSemantic proximity Read ↗

Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48.Semantic proximity Read ↗

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter.Semantic proximity Read ↗

Engineering and purification of a thermostable, high-yield, variant of PfCRT, the Plasmodium falciparum chloroquine resistance transporter.Semantic proximity Read ↗

The role of histidine residues in the HXGH site of CTP:phosphocholine cytidylyltransferase in CTP binding and catalysis.Semantic proximity Read ↗

Transport rates of a glutamate transporter homologue are influenced by the lipid bilayer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.