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Article

Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).

Biochemistry - 2 May 2017

Naffin-Olivos Jacqueline L, Daab Andrew, White Andre, Goldfarb Nathan E, Milne Amy C, Liu Dali, Baikovitz Jacqueline, Dunn Ben M, Rengarajan Jyothi, Petsko Gregory A, Ringe Dagmar

Abstract excerpt

The Mycobacterium tuberculosis (Mtb) serine protease Hip1 (hydrolase important for pathogenesis; Rv2224c) promotes tuberculosis (TB) pathogenesis by impairing host immune responses through proteolysis of a protein substrate, Mtb GroEL2. The cell surface localization of Hip1 and its immunomodulatory functions make Hip1 a good drug target for new adjunctive immune therapies for TB. Here, we report the crystal...

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Identifiers

PMID: 28346784
DOI: 10.1021/acs.biochem.6b01066
PMCID: PMC6033327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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