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Article

Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.

Structure (London, England : 1993) - 13 Oct 2010

Biswas Tapan, Small Jennifer, Vandal Omar, Odaira Toshiko, Deng Haiteng, Ehrt Sabine, Tsodikov Oleg V

Abstract excerpt

Rv3671c, a putative serine protease, is crucial for persistence of Mycobacterium tuberculosis in the hostile environment of the phagosome. We show that Rv3671c is required for M. tuberculosis resistance to oxidative stress in addition to its role in protection from acidification. Structural and biochemical analyses demonstrate that the periplasmic domain of Rv3671c is a functional serine protease of the...

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Identifiers

PMID: 20947023
DOI: 10.1016/j.str.2010.06.017
PMCID: PMC2955984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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