Article
WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel.
Scientific reports - 27 Mar 2017
Artibani Mara, Sims Andrew H, Slight Joan, Aitken Stuart, Thornburn Anna, Muir Morwenna, Brunton Valerie G, Del-Pozo Jorge, Morrison Linda R, Katz Elad, Hastie Nicholas D, Hohenstein Peter
Abstract excerpt
WT1 is a transcription factor which regulates the epithelial-mesenchymal balance during embryonic development and, if mutated, can lead to the formation of Wilms' tumour, the most common paediatric kidney cancer. Its expression has also been reported in several adult tumour types, including breast cancer, and usually correlates with poor outcome. However, published data is inconsistent and the role of WT1 in this...
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