Article
Notochordal cell conditioned medium (NCCM) regenerates end-stage human osteoarthritic articular chondrocytes and promotes a healthy phenotype.
Arthritis research & therapy - 2 Jun 2016
Müller Sebastian, Acevedo Lina, Wang Xiaomei, Karim M Zia, Matta Ajay, Mehrkens Arne, Schaeren Stefan, Feliciano Sandra, Jakob Marcel, Martin Ivan, Barbero Andrea, Erwin W Mark
Abstract excerpt
BACKGROUND: Notochordal cell conditioned medium (NCCM) derived from non-chondrodystrophic dogs has pro-anabolic and anti-catabolic effects upon nucleus pulposus (NP) cells. Here, for the first time, we assessed the ability of NCCM to influence the production of extracellular matrix and inflammatory proteins by healthy and osteoarthritic human chondrocytes within engineered cartilage tissues. We hypothesized that,...
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