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Article

Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity.

The Journal of pharmacology and experimental therapeutics - 1 May 2000

Domanski T L, He Y A, Harlow G R, Halpert J R

Abstract excerpt

The structural basis of cooperativity of progesterone hydroxylation catalyzed by human cytochrome P450 3A4 has been investigated. A recent study suggested that substitution of larger side chains at positions Leu-211 and Asp-214 partially mimics the action of effector by reducing the size of the active site. Based on predictions from molecular modeling that Phe-304 in the highly conserved I helix is involved in...

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PMID: 10773032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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