Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein interaction evolution from promiscuity to specificity with reduced flexibility in an increasingly complex network.

Scientific reports - 24 Mar 2017

Alhindi T, Zhang Z, Ruelens P, Coenen H, Degroote H, Iraci N, Geuten K

Abstract excerpt

A key question regarding protein evolution is how proteins adapt to the dynamic environment in which they function and how in turn their evolution shapes the protein interaction network. We used extant and resurrected ancestral plant MADS-domain transcription factors to understand how SEPALLATA3, a protein with hub and glue properties, evolved and takes part in network organization. Although the density of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to Fungal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Dynamics Simulation

Share to Protein Conformation

Share to Protein Interaction Domains and Motifs

Share to Protein Interaction Maps

Share to Proteins

Share to Septins

Source

Open in PubMed Open full text

Identifiers

PMID: 28337996
DOI: 10.1038/srep44948
PMCID: PMC5364480

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein interaction evolution from promiscuity to specificity with reduced flexibility in an increasingly complex network.PMID 28337996Read ↗

Molecular dimension explored in evolution to promote proteomic complexity.Semantic proximity Read ↗

Sequence motifs in MADS transcription factors responsible for specificity and diversification of protein-protein interaction.Semantic proximity Read ↗

Genomic Complexity Places Less Restrictions on the Evolution of Young Coexpression Networks than Protein-Protein Interactions.Semantic proximity Read ↗

Design principles of gene evolution for niche adaptation through changes in protein-protein interaction networks.Semantic proximity Read ↗

Tetramerization of MADS family transcription factors SEPALLATA3 and AGAMOUS is required for floral meristem determinacy in Arabidopsis.Semantic proximity Read ↗

DNA-binding properties of the MADS-domain transcription factor SEPALLATA3 and mutant variants characterized by SELEX-seq.Semantic proximity Read ↗

The intervening domain is required for DNA-binding and functional identity of plant MADS transcription factors.Semantic proximity Read ↗

Structure, function, and evolution of transient and obligate protein-protein interactions.Semantic proximity Read ↗

Relating three-dimensional structures to protein networks provides evolutionary insights.Semantic proximity Read ↗

Recurrent innovation of protein-protein interactions in the <i>Drosophila</i> piRNA pathwaySemantic proximity Read ↗

The evolution of domain arrangements in proteins and interaction networks.Semantic proximity Read ↗

Co-evolutionary analysis of domains in interacting proteins reveals insights into domain-domain interactions mediating protein-protein interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.