Article
The intervening domain is required for DNA-binding and functional identity of plant MADS transcription factors.
Nature communications - 6 Aug 2021
Lai Xuelei, Vega-Léon Rosario, Hugouvieux Veronique, Blanc-Mathieu Romain, van der Wal Froukje, Lucas Jérémy, Silva Catarina S, Jourdain Agnès, Muino Jose M, Nanao Max H, Immink Richard, Kaufmann Kerstin, Parcy François, Smaczniak Cezary, Zubieta Chloe
Abstract excerpt
The MADS transcription factors (TF) are an ancient eukaryotic protein family. In plants, the family is divided into two main lineages. Here, we demonstrate that DNA binding in both lineages absolutely requires a short amino acid sequence C-terminal to the MADS domain (M domain) called the Intervening domain (I domain) that was previously defined only in type II lineage MADS. Structural elucidation of the MI...
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