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Article

Molecular dimension explored in evolution to promote proteomic complexity.

Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 2004

Fernández Ariel, Berry R Stephen

Abstract excerpt

The architecture of present-day protein interaction networks depends on how protein associations evolved. Here, we explore how and why evolution-related mutations influence protein structure to promote protein associations, and thereby network development. We specifically address two questions: (i) How can protein folds remain conserved while proteins accommodate new binding partnerships as genes duplicate? (ii)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15347802
DOI: 10.1073/pnas.0405585101
PMCID: PMC518779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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