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Article

MERTK rs4374383 variant predicts incident nonalcoholic fatty liver disease and diabetes: role of mononuclear cell activation and adipokine response to dietary fat.

Human molecular genetics - 1 May 2017

Musso Giovanni, Cassader Maurizio, De Michieli Franco, Paschetta Elena, Pinach Silvia, Saba Francesca, Bongiovanni Daria, Framarin Luciana, Berrutti Mara, Leone Nicola, Corvisieri Stefania, Parente Renato, Molinaro Federica, Sircana Antonio, Bo Simona, Gambino Roberto

Abstract excerpt

The loss-of-function rs4374383 G > A variant in Myeloid-epithelial-reproductive Tyrosine Kinase (MERTK) gene has been linked to hepatic fibrosis in chronic liver diseases. MERTK is expressed by immune and non-immune cells involved in inflammation, metabolism and vascular homeostasis. We assessed the impact of MERTK rs4374383 G > A variant on nonalcoholic fatty liver disease (NAFLD) incidence and severity and on...

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Share to Adipokines
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Share to Non-alcoholic Fatty Liver Disease
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Source

Identifiers

PMID: 28334911
DOI: 10.1093/hmg/ddw400

Genes

MERTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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