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Article

Evolutionary changes in cis and trans gene regulation.

Nature - 1 Jul 2004

Wittkopp Patricia J, Haerum Belinda K, Clark Andrew G

Abstract excerpt

Differences in gene expression are central to evolution. Such differences can arise from cis-regulatory changes that affect transcription initiation, transcription rate and/or transcript stability in an allele-specific manner, or from trans-regulatory changes that modify the activity or expression of factors that interact with cis-regulatory sequences. Both cis- and trans-regulatory changes contribute to...

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PMID: 15229602
DOI: 10.1038/nature02698

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