Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The hypomorphic TERT A1062T variant is associated with increased treatment-related toxicity in acute myeloid leukemia.

Annals of hematology - 1 Jun 2017

Both Anna, Krauter Jürgen, Damm Frederik, Thol Felicitas, Göhring Gudrun, Heuser Michael, Ottmann Oliver, Lübbert Michael, Wattad Mohammed, Kanz Lothar, Schlimok Günter, Raghavachar Aruna, Fiedler Walter, Kirchner Hartmut, Brugger Wolfram, Schlegelberger Brigitte, Heil Gerhard, Ganser Arnold, Wagner Katharina

Abstract excerpt

Hypomorphic germline variants in TERT, the gene encoding the reverse transcriptase component of the human telomerase complex, occur with a frequency of 3-5% in acute myeloid leukemia. We analyzed the clinical and prognostic impact of the most common TERT A1062T variant in younger patients with acute myeloid leukemia intensively treated within two prospective multicenter trials. Four hundred and twenty patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Clinical Trials as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Combined Modality Therapy

Share to Diarrhea

Share to Leukemia, Myeloid

Share to Multicenter Studies as Topic

Share to Stem Cell Transplantation

Share to Telomerase

Source

Identifiers

PMID: 28331964
DOI: 10.1007/s00277-017-2967-0

Genes

TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The hypomorphic TERT A1062T variant is associated with increased treatment-related toxicity in acute myeloid leukemia.PMID 28331964Read ↗

Telomerase reverse transcriptase (TERT) A1062T mutation as a prognostic factor in Egyptian patients with acute myeloid leukemia (AML).Semantic proximity Read ↗

Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia.Semantic proximity Read ↗

Association between TERT promoter polymorphisms and acute myeloid leukemia risk and prognosis.Semantic proximity Read ↗

TERT Genotype Polymorphism: A Glance of Change Egyptian MDS Outcomes.Semantic proximity Read ↗

Genetic regulation of<i>TERT</i>splicing contributes to reduced or elevated cancer risk by altering cellular longevity and replicative potentialSemantic proximity Read ↗

Genetic regulation of TERT splicing affects cancer risk by altering cellular longevity and replicative potentialSemantic proximity Read ↗

The clinical and functional effects of <i>TERT</i> variants in myelodysplastic syndromeSemantic proximity Read ↗

Variation at the TERT locus and predisposition for cancer.Semantic proximity Read ↗

The clinical and functional effects of TERT variants in myelodysplastic syndrome.Semantic proximity Read ↗

Novel telomerase reverse transcriptase gene mutation in a family with aplastic anaemia.Semantic proximity Read ↗

Discovery and characterization of a novel telomerase alternative splicing isoform that protects lung cancer cells from chemotherapy induced cell death.Semantic proximity Read ↗

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.