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Article

The influence of genetic susceptibility and calcium plus vitamin D supplementation on fracture risk.

The American journal of clinical nutrition - 1 Apr 2017

Wang Youjin, Wactawski-Wende Jean, Sucheston-Campbell Lara E, Preus Leah, Hovey Kathleen M, Nie Jing, Jackson Rebecca D, Handelman Samuel K, Nassir Rami, Crandall Carolyn J, Ochs-Balcom Heather M

Abstract excerpt

Background: Fracture is a complex trait, affected by both genetic and environmental factors. A meta-analysis of genome-wide association studies (GWASs) identified multiple bone mineral density (BMD) and fracture-associated loci.Objective: We conducted a study to evaluate whether fracture genetic risk score (Fx-GRS) and bone mineral density genetic risk score (BMD-GRS) modify the association between the intake of...

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Identifiers

PMID: 28148500
DOI: 10.3945/ajcn.116.144550
PMCID: PMC5366049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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