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Article

Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer.

Paediatric anaesthesia - 1 Jul 2007

Voronov Polina, Przybylo Henry J, Jagannathan Narasimhan

Abstract excerpt

We present a case of a 29 months old previously healthy child who experienced apnea resulting in brain injury following a dose of acetaminophen and codeine 2 days after an uneventful anesthetic for tonsillectomy. A genetic polymorphism leading to ultra-rapid metabolism of codeine into morphine resulted in narcosis and apnea. This paper discusses the use of codeine for pain relief, obstructive sleep apnea, the...

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Share to Acetaminophen
Share to Analgesics, Non-Narcotic
Share to Analgesics, Opioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Codeine

Share to Cytochrome P-450 CYP2D6

Share to Polymorphism, Genetic

Share to Sleep Apnea Syndromes

Source

Identifiers

PMID: 17564651
DOI: 10.1111/j.1460-9592.2006.02182.x

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