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Article

DNA methyltransferase 1 rs16999593 genetic polymorphism decreases risk in patients with transposition of great arteries.

Gene - 5 Jun 2017

Lei Liming, Lin Haoming, Zhong Shilong, Zhang Zhiwei, Chen Jimei, Yu Xiyong, Liu Xiaoqing, Zhang Cheng, Nie Zhiqiang, Zhuang Jian

Abstract excerpt

Complete transposition of the great arteries (TGA) is the most frequent cyanotic heart defect diagnosed in neonates. However, the exact etiology of TGA is unknown. The aim of the present study was to assess the association of TGA pathogenesis with single nucleotide polymorphisms (SNPs) in DNA methyltransferases (DNMTs)-1 and 3a- in Chinese children. We genotyped 5 SNPs (rs16999593, rs16999358, and rs2228611 in...

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Identifiers

PMID: 28323001
DOI: 10.1016/j.gene.2017.03.012

Genes

DNMT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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