Article
BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action
20 Mar 2017
Abstract excerpt
Abstract Polybrominated diphenyl ethers (PBDEs) are bioaccumulating flame retardants causing developmental neurotoxicity (DNT) in humans and rodents. Their DNT effects are suspected to involve thyroid hormone (TH) signaling disruption. Here, we tested the hypothesis whether disturbance of neural progenitor cell (NPC) differentiation into the oligodendrocyte lineage (O4+cells) by BDE-99 involves disruption of TH...