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Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility.

Circulation - 2 May 2017

Wang Dan, Wang Feng, Shi Kai-Hu, Tao Hui, Li Yang, Zhao Rui, Lu Han, Duan Wenyuan, Qiao Bin, Zhao Shi-Min, Wang Hongyan, Zhao Jian-Yuan

Abstract excerpt

BACKGROUND: Folate deficiency is an independent risk factor for congenital heart disease (CHD); however, the maternal plasma folate level is paradoxically not a good diagnostic marker. Genome-wide surveys have identified variants of nonfolate metabolic genes associated with the plasma folate level, suggesting that these genetic polymorphisms are potential risk factors for CHD. METHODS: To examine the effects of...

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PMID: 28302752
DOI: 10.1161/CIRCULATIONAHA.116.025164

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FIGN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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