Article
Precision and prognostic value of clone-specific minimal residual disease in acute myeloid leukemia.
Haematologica - 1 Jul 2017
Hirsch Pierre, Tang Ruoping, Abermil Nassera, Flandrin Pascale, Moatti Hannah, Favale Fabrizia, Suner Ludovic, Lorre Florence, Marzac Christophe, Fava Fanny, Mamez Anne-Claire, Lapusan Simona, Isnard Françoise, Mohty Mohamad, Legrand Ollivier, Douay Luc, Bilhou-Nabera Chrystele, Delhommeau François
Abstract excerpt
The genetic landscape of adult acute myeloid leukemias (AML) has been recently unraveled. However, due to their genetic heterogeneity, only a handful of markers are currently used for the evaluation of minimal residual disease (MRD). Recent studies using multi-target strategies indicate that detection of residual mutations in less than 5% of cells in complete remission is associated with a better survival. Here,...
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