A novel deep targeted sequencing method for minimal residual disease monitoring in acute myeloid leukemia.

doi:10.3324/haematol.2018.194712

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Article

A novel deep targeted sequencing method for minimal residual disease monitoring in acute myeloid leukemia.

Haematologica - 1 Feb 2019

Onecha Esther, Linares Maria, Rapado Inmaculada, Ruiz-Heredia Yanira, Martinez-Sanchez Pilar, Cedena Teresa, Pratcorona Marta, Oteyza Jaime Perez, Herrera Pilar, Barragan Eva, Montesinos Pau, Vela Jose Antonio Garcia, Magro Elena, Anguita Eduardo, Figuera Angela, Riaza Rosalia, Martinez-Barranco Pilar, Sanchez-Vega Beatriz, Nomdedeu Josep, Gallardo Miguel, Martinez-Lopez Joaquin, Ayala Rosa

Abstract excerpt

A high proportion of patients with acute myeloid leukemia who achieve minimal residual disease negative status ultimately relapse because a fraction of pathological clones remains undetected by standard methods. We designed and validated a high-throughput sequencing method for minimal residual disease assessment of cell clonotypes with mutations of NPM1, IDH1/2 and/or FLT3-single nucleotide variants. For clinical...

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Identifiers

PMID: 30093399
DOI: 10.3324/haematol.2018.194712
PMCID: PMC6355493

Genes

FLT3
IDH1
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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