Article
Slow protein evolutionary rates are dictated by surface-core association.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2011
Tóth-Petróczy Agnes, Tawfik Dan S
Abstract excerpt
Why do certain proteins evolve much slower than others? We compared not only rates per protein, but also rates per position within individual proteins. For ∼90% of proteins, the distribution of positional rates exhibits three peaks: a peak of slow evolving residues, with average log(2)[normalized rate], log(2)μ, of ca. -2, corresponding primarily to core residues; a peak of fast evolving residues (log(2)μ ∼ 0.5)...
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