Article
Prediction of breast cancer risk based on flow-variant analysis of circulating peripheral blood B cells.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Sept 2017
Syeda Mahrukh M, Upadhyay Kinnari, Loke Johnny, Pearlman Alexander, Klugman Susan, Shao Yongzhao, Ostrer Harry
Abstract excerpt
PURPOSE: Identifying women at high risk for breast cancer can trigger a personal program of annual mammograms and magnetic resonance imaging scans for early detection, prophylactic surgery, or chemoprevention to reduce the risk of cancer. Yet, current strategies to identify high-risk mutations based on sequencing panels of genes have significant false-positive and false-negative results, suggesting the need for...
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