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Article

Disruption of protein complexes containing protein phosphatase 2B and Munc18c reduces the secretion of von Willebrand factor from endothelial cells.

Journal of thrombosis and haemostasis : JTH - 1 May 2017

Da Q, Shaw T, Pradhan S, Roche P A, Cruz M A, Vijayan K Vinod

Abstract excerpt

Essentials Endothelial secretion of von Willebrand factor (VWF) promotes inflammation and thrombosis. We studied the role of protein phosphatase 2B (PP2B) and Munc18c protein complex in VWF secretion. Disruption of PP2B-Munc18c complex in endothelial cells reduced agonist-induced VWF secretion. PP2B-Munc18c complex represents a potential target for thrombotic and inflammatory conditions. SUMMARY: Background...

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Identifiers

PMID: 28294518
DOI: 10.1111/jth.13671
PMCID: PMC5413388

Genes

VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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