Article
Multiepitope tissue analysis reveals SPPL3-mediated ADAM10 activation as a key step in the transformation of melanocytes.
Science signaling - 14 Mar 2017
Ostalecki Christian, Lee Jung-Hyun, Dindorf Jochen, Collenburg Lena, Schierer Stephan, Simon Beate, Schliep Stefan, Kremmer Elisabeth, Schuler Gerold, Baur Andreas S
Abstract excerpt
The evolution of cancer is characterized by the appearance of specific mutations, but these mutations are translated into proteins that must cooperate to induce malignant transformation. Using a systemic approach with the multiepitope ligand cartography (MELC) technology, we analyzed protein expression profiles (PEPs) in nevi and BRAFV600E-positive superficial spreading melanomas (SSMs) from patient tissues to...
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