Article
Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers.
JAMA neurology - 1 Dec 2014
Liu Qing, Waltz Shannon, Woodruff Grace, Ouyang Joe, Israel Mason A, Herrera Cheryl, Sarsoza Floyd, Tanzi Rudolph E, Koo Edward H, Ringman John M, Goldstein Lawrence S B, Wagner Steven L, Yuan Shauna H
Abstract excerpt
IMPORTANCE: Although considerable effort has been expended developing drug candidates for Alzheimer disease, none have yet succeeded owing to the lack of efficacy or to safety concerns. One potential shortcoming of current approaches to Alzheimer disease drug discovery and development is that they rely primarily on transformed cell lines and animal models that substantially overexpress wild-type or mutant...
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