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Article

Simultaneous determination of glipizide and its four hydroxylated metabolites in human urine using LC-MS/MS and its application in urinary phenotype study.

Journal of pharmaceutical and biomedical analysis - 30 May 2017

Tan Bo, Yang Aidong, Yuan Weian, Li Yue, Jiang Lei, Jiang Jian, Qiu Furong

Abstract excerpt

Cytochrome P450 (CYP) 2C9 and CYP2C19 genetic mutant could influence the plasma concentration of glipizide in human subjects, which refers to glipizide safety and adverse effects in clinic practice. A further study to investigate the relationship of the concentrations between glipizide and its metabolites in human with different CYP mutants was valuable. We firstly develop a validated liquid chromatography-tandem...

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PMID: 28284082
DOI: 10.1016/j.jpba.2017.03.005

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