Article
A new simple method for quantification of cilostazol and its active metabolite in human plasma by LC-MS/MS: Application to pharmacokinetics of cilostazol associated with CYP genotypes in healthy Chinese population.
Biomedical chromatography : BMC - 1 Oct 2021
Shen Yuting, Jiang Bo, Hu Xinhua, Chen Jinliang, Xu Yichao, Ruan Zourong, Yang Dandan, Lou Honggang
Abstract excerpt
A simple, sensitive, and fully automated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous quantification of cilostazol (CIL) and its active metabolite, 3,4-dehydro cilostazol (CIL-M), in human plasma. Plasma samples were processed by protein precipitation in 2 mL 96-deep-well plates, and all liquid transfer steps were performed through robotic...
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