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Article

TRIB3 Stabilizes High TWIST1 Expression to Promote Rapid APL Progression and ATRA Resistance

24 Jun 2019

Abstract excerpt

Abstract Purpose: The resistance to differentiation therapy and early death caused by fatal bleeding endangers the health of a significant proportion of patients with acute promyelocytic leukemia (APL). This study aims to investigate the molecular mechanisms of all-trans retinoic acid (ATRA) resistance and uncover new potential therapeutic strategies to block the rapid progression of early death. Experimental...

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Share to Acute Myeloid Leukemia Research
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Share to Retinoids in leukemia and cellular processes

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PMID: 31235507
DOI: 10.1158/1078-0432.ccr-19-0510

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