Article
A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes.
FEBS letters - 1 Apr 2017
Nishi-Tatsumi Makiko, Yahagi Naoya, Takeuchi Yoshinori, Toya Naoki, Takarada Ayako, Murayama Yuki, Aita Yuichi, Sawada Yoshikazu, Piao Xiaoying, Oya Yukari, Shikama Akito, Masuda Yukari, Kubota Midori, Izumida Yoshihiko, Matsuzaka Takashi, Nakagawa Yoshimi, Sekiya Motohiro, Iizuka Yoko, Kawakami Yasushi, Kadowaki Takashi, Yamada Nobuhiro, Shimano Hitoshi
Abstract excerpt
Fatty acid synthase (Fasn) is a key component of energy metabolism that is dynamically induced by food intake. Although extensive studies have revealed a number of transcription factors involved in the fasting/refeeding transition of Fasn expression in hepatocytes, much less evidence is available for adipocytes. Using the in vivo Ad-luc analytical system, we identified the inverted CCAAT element (ICE) around -100...
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