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Article

Association of genetic polymorphisms of claudin-1 with small vessel vascular dementia.

Clinical and experimental pharmacology & physiology - 1 Jun 2017

Srinivasan Vivek, Braidy Nady, Xu Ying Hua, Xie Peter, Kancherla Kiran, Chandramohan Sashiruben, Chan Eunice Kar Wing, Chan Daniel Ky

Abstract excerpt

The most recent hypothesis of the development of small vessel vascular dementia (VaD) emphasises the role of blood-brain barrier (BBB) dysfunction. It is hypothesised that certain genetic polymorphisms of the BBB tight junction claudin-1 protein, in combination with adverse environmental risk factors, increase the risk of BBB dysfunction and small vessel VaD. In this case-control study, 97 control participants,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28273404
DOI: 10.1111/1440-1681.12747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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