Article
Gene-set meta-analysis of lung cancer identifies pathway related to systemic lupus erythematosus.
PloS one - 1 Jan 2017
Rosenberger Albert, Sohns Melanie, Friedrichs Stefanie, Hung Rayjean J, Fehringer Gord, McLaughlin John, Amos Christopher I, Brennan Paul, Risch Angela, Brüske Irene, Caporaso Neil E, Landi Maria Teresa, Christiani David C, Wei Yongyue, Bickeböller Heike
Abstract excerpt
INTRODUCTION: Gene-set analysis (GSA) is an approach using the results of single-marker genome-wide association studies when investigating pathways as a whole with respect to the genetic basis of a disease. METHODS: We performed a meta-analysis of seven GSAs for lung cancer, applying the method META-GSA. Overall, the information taken from 11,365 cases and 22,505 controls from within the TRICL/ILCCO consortia was...
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