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Article

The role of N-glycosylation in folding, trafficking, and functionality of lysosomal protein CLN5.

PloS one - 1 Jan 2013

Moharir Akshay, Peck Sun H, Budden Theodore, Lee Stella Y

Abstract excerpt

CLN5 is a soluble lysosomal protein with unknown function. Mutations in CLN5 lead to neuronal ceroid lipofuscinosis, a group of inherited neurodegenerative disorders that mainly affect children. CLN5 has eight potential N-glycosylation sites based on the Asn-X-Thr/Ser consensus sequence. Through site-directed mutagenesis of individual asparagine residues to glutamine on each of the N-glycosylation consensus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24058541
DOI: 10.1371/journal.pone.0074299
PMCID: PMC3769244

Genes

CLN5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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