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Article

ATIC Gene Polymorphism and Histologic Response to Chemotherapy in Pediatric Osteosarcoma.

Journal of pediatric hematology/oncology - 1 Jul 2017

Park Jeong A, Shin Hee Young

Abstract excerpt

Accumulating evidence indicates that polymorphisms in folate pathway genes play a role in response to methotrexate (MTX) treatment in various diseases. This study explored the influence of these genetic polymorphisms on treatment outcome in pediatric osteosarcoma. Blood and tissue samples from 48 osteosarcoma patients were obtained, and the following polymorphisms were analyzed; SLC19A1 80G>A, DHFR 829C>T, MTHFR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28267080
DOI: 10.1097/MPH.0000000000000802

Genes

ATIC
MTHFR
DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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