Article
EGFR inhibition abrogates leiomyosarcoma cell chemoresistance through inactivation of survival pathways and impairment of CSC potential.
PloS one - 1 Jan 2012
Sette Giovanni, Salvati Valentina, Memeo Lorenzo, Fecchi Katia, Colarossi Cristina, Di Matteo Paola, Signore Michele, Biffoni Mauro, D'Andrea Vito, De Antoni Enrico, Canzonieri Vincenzo, De Maria Ruggero, Eramo Adriana
Abstract excerpt
BACKGROUND: Tumor cells with stem-like phenotype and properties, known as cancer stem cells (CSC), have been identified in most solid tumors and are presumed to be responsible for driving tumor initiation, chemoresistance, relapse, or metastasis. A subpopulation of cells with increased stem-like potential has also been identified within sarcomas. These cells are endowed with increased tumorigenic potential,...
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